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Yu Feiyan;;Xu Na;;Zhou Yu;;Li Baoyin;;Li Miao;;Wang Qianqian;;Yang Xi;;Ge Xuejun;;Zhang Fang;;Ren Xiuyun£¬ Oral diseases PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-08-08 ÊÕ²Ø 3 Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy Jin Wen;;Bin Xu;;Yuchao Sun;;Mengqiao Lian;;Yanli Li;;Yuan Lin;;Dapeng Chen;;Yunpeng Diao;;Marwan Almoiliqy;;Li Wang£¬ Pharmacological Research Elsevierjournal ·¢±íʱ¼ä£º2019-08-05 ÊÕ²Ø 4 Paeoniflorin protects spiral ganglion neurons from cisplatin-induced ototoxicity: Possible relation to PINK1/BAD pathway. Yu Xiaoyu;;Man Rongjun;;Li Yanan;;Yang Qianqian;;Li Hongrui;;Yang Huiming;;Bai Xiaohui;;Yin Haiyan;;Li Jianfeng;;Wang Haibo£¬ Journal of cellular and molecular medicine PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-08-05 ÊÕ²Ø 5 Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy. Wen Jin;;Xu Bin;;Sun Yuchao;;Lian Mengqiao;;Li Yanli;;Lin Yuan;;Chen Dapeng;;Diao Yunpeng;;Almoiliqy Marwan;;Wang Li£¬ Pharmacological research PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-08-05 ÊÕ²Ø 6 ÉÖÒ©ÜÕ´Ù½øÌÇÄò²¡´´ÃæÓúºÏ ·¿Ö¾Èñ;³Âè´;Àî´ºÏþ;ËÎÃô;ÕÅè´É¯;Joel Wake Coffie;ÕÅÀöæÂ;Âíè´è´;Íõºç;£¬ ÖйúÒ©Àíѧͨ±¨ 2019Äê08ÆÚ £¬ ÆÚ¿¯ Ä¿µÄ Ñо¿ÉÖÒ©ÜÕ(paeoniflorin,PA)¶ÔÌÇÄò²¡´´ÃæÓúºÏ×÷Óü°×÷ÓûúÖÆ¡£·½·¨ ²ÉÓÃÌÇÄò²¡Ð¡ÊóÈ«²ãƤ·ôÇгý¼Ð°åÄ£ÐÍ,HEȾɫ¼°MassonȾɫ¹Û²ì´´Ãæ×éÖ¯ÐÎ̬¸Ä±ä;ÃâÒßÓ«¹â·¨¼ì²âѪ¹ÜÐÂÉú¡£PA¸ÉÔ¤ÈËÆê¾²ÂöÄÚÆ¤Ï¸°û(human umbilical vein endothelial cells,HUVECs)ºÍСÊó³ÉÏËάϸ°û(fibroblast,FB),MTS¡¢Brd UºÍ»®ºÛʵÑé¼ì²âϸ°ûÔöÖ³ºÍÇ¨ÒÆÄÜÁ¦; MatrigelʵÑé¼ì²âHUVECs³É¹ÜÄÜÁ¦,q PCR¼ì²â ÏÂÔØÆµ´Î£º19 ·¢±íʱ¼ä£º2019-07-31 09:52 ÊÕ²Ø 7 ¸ßЧҺÏàÉ«Æ×¶à²¨³¤·¨Í¬Ê±²â¶¨ÖзçºÏ¼ÁÖÐè÷´¼¡¢¹þ°ÍÜÕ¡¢ÂÌÔËáºÍÉÖÒ©ÜÕº¬Á¿ ½½¨Àö;£¬ ÖйúÒ©Òµ 2019Äê15ÆÚ £¬ ÆÚ¿¯ Ä¿µÄ½¨Á¢Í¬Ê±²â¶¨ÖзçºÏ¼ÁÖÐè÷´¼¡¢¹þ°ÍÜÕ¡¢ÂÌÔËáºÍÉÖÒ©ÜÕ4ÖÖÓÐЧ³É·Öº¬Á¿µÄ¸ßЧҺÏàÉ«Æ×¶à²¨³¤·¨¡£·½·¨É«Æ×ÖùΪWelch XB-C18Öù(250 mm¡Á4. 6 mm,5¦Ìm),Á÷¶¯ÏàAΪ0. 06%Á×ËáÈÜÒº¡¢BΪÒÒëæ(ÌݶÈÏ´ÍÑ),Á÷ËÙΪ1. 0 m L/min,¼ì²â²¨³¤·Ö±ðΪ200,231,327 nm,ÖùÎÂΪ30¡æ,½øÑùÁ¿Îª10¦ÌL¡£½á¹ûè÷´¼¡¢¹þ°ÍÜÕ¡¢ÂÌÔËá¡¢ÉÖÒ©ÜÕ½øÑùÁ¿·Ö±ðÔÚ0. 156¡«1. 248¦Ìg,0. 154¡«1. 232¦Ìg,0. 136¡«1. 086¦Ìg, ÏÂÔØÆµ´Î£º26 ·¢±íʱ¼ä£º2019-07-30 ÊÕ²Ø 8 HPLC·¨²â¶¨åÐÒ£ÌÀÖÐÉÖÒ©Üյĺ¬Á¿²â¶¨ ÖÜÕÜ; ÃÏÏþ±ò; ÕÔ²©£¬ ¹óÑôÖÐҽѧԺѧ±¨ 2019Äê04ÆÚ £¬ ÆÚ¿¯ Ä¿µÄ:½¨Á¢ÒÔ¸ßЧҺÏàÉ«Æ×·¨²â¶¨åÐÒ£ÌÀÖÐÉÖÒ©Üյĺ¬Á¿²â¶¨·½·¨¡£·½·¨:É«Æ×ÖùΪAgilent ZORBAX SB-C18Öù£¨4.6¡Á250mm,5¦Ìm£©,Á÷¶¯ÏàΪÒÒëæ-0.1%Á×ËáË®£¨14¡Ã86£©;ÖùÎÂΪ30¡æ,Á÷ËÙΪ1mL¡¤min-1,¼ì²â²¨³¤Îª230 nm,½øÑùÁ¿Îª10¦ÌL¡£½á¹û:±íÃ÷ÉÖÒ©ÜÕÔÚ21.40¡«149.8¦Ìg¡¤mL-1Ö®¼äÏßÐÔ¹ØÏµÁ¼ºÃ£¨r=0.9997£©,ƽ¾ù»ØÊÕÂÊΪ101.57%,RSD 1.0%¡£½áÂÛ:±¾·¨¼ò±ã¡¢¿ìËÙ¡¢Öظ´ÐÔºÃ,¿ÉÓÃÓÚåÐÒ£ÌÀµÄÖÊÁ¿ ÏÂÔØÆµ´Î£º5 ·¢±íʱ¼ä£º2019-07-30 ÊÕ²Ø 9 Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma. Yu Guoyong;;Wang Zhaotao;;Zeng Shulian;;Liu Sisi;;Zhu Chunping;;Xu Ruxiang;;Liu Ru-En£¬ BioMed research international PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-07-23 ÊÕ²Ø 10 HPLCͬʱ²â¶¨·»ÆºÏ¼ÁÖÐÉÖÒ©ÜÕºÍÑÎËáСé޼Á¿ ½·ïç÷; Öܺ£æÉ; ³ÂÎijÉ; ¸Ê±óÑÞ; ÍõÑÇ·¼£¬ ÖйúÊÞÒ©ÔÓÖ¾ 2019Äê07ÆÚ £¬ ÆÚ¿¯ ΪÁ˲ⶨ·»ÆºÏ¼ÁÖÐÉÖÒ©ÜÕºÍÑÎËáСéÞ¼îµÄº¬Á¿¡£²ÉÓÃÖÐÐÔÑõ»¯ÂÁÖù¶Ô¹©ÊÔÆ·ÈÜÒº½øÐд¦Àí,ʹĿ±ê·å²»±»ÔÓÖÊ·å¸ÉÈÅ¡£²ÉÓÃYMC-Pack Pro C18É«Æ×Öù(250¡Á4. 6 mm),Á÷¶¯ÏàΪÒÒëæ-0.15%Á×ËáÈÜÒº(ÌݶÈÏ´ÍÑ),Á÷ËÙΪ1.0 m L/min,ÖùÎÂΪ26¡æ,¼ì²â²¨³¤Îª245 nm,½¨Á¢Á˸ßЧҺÏàÉ«Æ×²â¶¨·½·¨¡£ÉÖÒ©ÜÕºÍÑÎËáСéÞ¼îµÄ½øÑùÁ¿·Ö±ðÔÚ0.307¡«4.920¦Ìg(r=0.9996)ºÍ0. 064¡«1.025¦Ìg(r=0.9998)·¶Î§ÄÚÓë·åÃæ»ý³ÊÁ¼ºÃµÄÏßÐÔ¹ØÏµ ÏÂÔØÆµ´Î£º5 ·¢±íʱ¼ä£º2019-07-20 ÊÕ²Ø 11 ÉÖÒ©ÜÕ¶ÔËèºËϸ°ûÔöÖ³µÄÓ°Ïì ÍõÐÂÁ¢; ÁõÈêÒø; ÍõÎ÷±ò; ÔÀ×Ú½ø£¬ ÖгÉÒ© 2019Äê07ÆÚ £¬ ÆÚ¿¯ Ä¿µÄ̽ÌÖÉÖÒ©ÜÕ¶ÔËèºËϸ°ûÔöÖ³µÄÓ°Ïì¡£·½·¨·ÖÀëÅàÑø7ÖÜÁäÐÛÐÔSD´óÊóËèºËϸ°û¼ÓÈ벻ͬŨ¶È(0¡¢0.5¡¢1¡¢2¡¢5¡¢8¡¢10¡¢15¡¢20¡¢25¦Ìmol/L)ÉÖÒ©ÜÕºó,MTT¡¢BrdU·¨¼ì²âϸ°û»îÁ¦ºÍÔöÖ³,qRT-PCR¼ì²âc-fos¡¢p27 mRNA±í´ï,Western blot¼ì²âc-fos¡¢p27µ°°×±í´ï¡£½á¹ûÖÕŨ¶È8¡«20¦Ìmol/LµÄÉÖÒ©ÜÕÏÔÖøÉϵ÷ϸ°û»îÁ¦ºÍÔöÖ³(P<0.05,P<0.01),³Ê¼ÁÁ¿ÒÀÀµÐÔ¡£8¦Ìmol/LÉÖÒ©ÜÕÏÔÖøÒÖÖÆc-fos¡¢p27 mRNAºÍµ°°× ÏÂÔØÆµ´Î£º24 ·¢±íʱ¼ä£º2019-07-19 ÊÕ²Ø 12 Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities. 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Shao Yun-Xia;;Gong Qian;;Qi Xiang-Ming;;Wang Kun;;Wu Yong-Gui£¬ Frontiers in pharmacology PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-06-19 ÊÕ²Ø 18 Effect of paeoniflorin on cardiac remodeling in chronic heart failure rats through the transforming growth factor ¦Â1/Smad signaling pathway. Liu Mao;;Ai Jiao;;Feng Jie;;Zheng Jiankang;;Tang Kai;;Shuai Zhuang;;Yang Jingxi£¬ Cardiovascular diagnosis and therapy PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-06-12 ÊÕ²Ø 19 HPLCͬʱ²â¶¨À¤Ì©½ºÄÒÖÐëÈﻨÌÇÜÕ¡¢ÉÖÒ©ÜպͻÆÜËÜÕº¬Á¿ Ö£°¢Ðñ£¬ ÖйúÏÖ´úÓ¦ÓÃҩѧ 2019Äê11ÆÚ £¬ ÆÚ¿¯ Ä¿µÄ½¨Á¢HPLCͬʱ²â¶¨À¤Ì©½ºÄÒÖÐëÈﻨÌÇÜÕ¡¢ÉÖÒ©ÜպͻÆÜËÜÕº¬Á¿µÄ·½·¨,ΪÍêÉÆÏÖÓÐÖÊÁ¿±ê×¼Ìṩ²Î¿¼¡£·½·¨²ÉÓÃPhenomsil C18£¨4.6 mm¡Á250 mm,5¦Ìm£©É«Æ×Öù;ÒÔÒÒëæÎªÁ÷¶¯ÏàA,ÒÔ0.1%ÒÒËáΪÁ÷¶¯ÏàB,²ÉÓÃÌݶÈÏ´ÍÑ;Á÷ËÙΪ1.0 mL¡¤min-1;ÖùÎÂΪ35¡æ;ëÈﻨÌÇÜյļì²â²¨³¤Îª334 nm,ÉÖÒ©ÜÕ¼ì²â²¨³¤Îª230 nm,»ÆÜËÜյļì²â²¨³¤Îª280 nm¡£½á¹ûëÈﻨÌÇÜÕÔÚ3.27¡«32.68¦Ìg¡¤mL-1ÄÚÏßÐÔ¹ØÏµÁ¼ºÃ,ƽ¾ù»ØÊÕÂÊΪ98 ÏÂÔØÆµ´Î£º118 ·¢±íʱ¼ä£º2019-06-11 15:37 ÊÕ²Ø 20 In vivo microdialysis and in vitro HPLC analysis of the impact of paeoniflorin on the monoamine levels and their metabolites in the rodent brain. Lin Yuh-Tzy;;Huang Wei-Shih;;Tsai Huei-Yann;;Lee Min-Min;;Chen Yuh-Fung£¬ BioMedicine PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-06-03 ÊÕ²Ø 21 Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin. Yu Jin-Bo;;Zhao Zhen-Xiong;;Peng Ran;;Pan Li-Bin;;Fu Jie;;Ma Shu-Rong;;Han Pei;;Cong Lin;;Zhang Zheng-Wei;;Sun Li-Xin;;Jiang Jian-Dong;;Wang Yan£¬ Frontiers in pharmacology PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-06-02 ÊÕ²Ø 22 A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKC ¦Â 1. Wang Jing-Shang;;Huang Ye;;Zhang Shuping;;Yin Hui-Jun;;Zhang Lei;;Zhang Yan-Hong;;Song Ye-Wen;;Li Dan-Dan£¬ Oxidative medicine and cellular longevity PubMedÆÚ¿¯ ·¢±íʱ¼ä£º2019-06-02 ÊÕ²Ø 23 The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6'-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases. 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